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Diverse Effects of Platelet-Derived Growth factor-BB on Cell Signaling Pathways

Diverse Effects of Platelet-Derived Growth factor-BB on Cell Signaling Pathways

Chenbing Wang, Yanbo Liu, Dongning He

Cytokine. 2019 Jan;113:13-20.

PMID: 30539778

Abstract:

Platelet-derived growth factor-BB (PDGF-BB) is involved in the tissue repair and tumor progression effects, and act as a rapid and early effector cytokines which are released in response to pathogen-induced changes in the microenvironment. Recent researches have implicated PDGF-BB as a potential contributing factor to the spectrum of the cell signaling pathway of interrelated diseases, particularly mesangial cells, mesenchymal stem cells, human dermal fibroblasts, tumor pericytes and smooth muscle cells. In this review, we generalize the present literatures on the roles of PDGF-BB in the various interrelated diseases, providing insights or strategies into the underlying cellular and signaling mechanisms that will help guide future studies further into promising interventional targets with therapeutic potential.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248631	Platelet-Derived Growth Factor-BB human			Price

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