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Diversification of Human Plasmacytoid Predendritic Cells in Response to a Single Stimulus

Diversification of Human Plasmacytoid Predendritic Cells in Response to a Single Stimulus

Solana G Alculumbre, Violaine Saint-André, Jeremy Di Domizio, Pablo Vargas, Philemon Sirven, Pierre Bost, Mathieu Maurin, Paolo Maiuri, Maxime Wery, Mabel San Roman, Léa Savey, Maxime Touzot, Benjamin Terrier, etc.

Nat Immunol. 2018 Jan;19(1):63-75.

PMID: 29203862

Abstract:

Innate immune cells adjust to microbial and inflammatory stimuli through a process termed environmental plasticity, which links a given individual stimulus to a unique activated state. Here, we report that activation of human plasmacytoid predendritic cells (pDCs) with a single microbial or cytokine stimulus triggers cell diversification into three stable subpopulations (P1-P3). P1-pDCs (PD-L1+CD80-) displayed a plasmacytoid morphology and specialization for type I interferon production. P3-pDCs (PD-L1-CD80+) adopted a dendritic morphology and adaptive immune functions. P2-pDCs (PD-L1+CD80+) displayed both innate and adaptive functions. Each subpopulation expressed a specific coding- and long-noncoding-RNA signature and was stable after secondary stimulation. P1-pDCs were detected in samples from patients with lupus or psoriasis. pDC diversification was independent of cell divisions or preexisting heterogeneity within steady-state pDCs but was controlled by a TNF autocrine and/or paracrine communication loop. Our findings reveal a novel mechanism for diversity and division of labor in innate immune cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413180	CD80 human			Price

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