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Do 5-HT4 Receptors Mediate the Intestinal Secretory Response to 5-HT in Rat In-Vivo?

Do 5-HT4 Receptors Mediate the Intestinal Secretory Response to 5-HT in Rat In-Vivo?

C M Franks, J Hardcastle, P T Hardcastle, G J Sanger

J Pharm Pharmacol. 1995 Mar;47(3):213-8.

PMID: 7602483

Abstract:

The involvement of the recently characterized 5-HT4 receptor in the actions of 5-hydroxytryptamine (5-HT) on jejunal, ileal and colonic electrogenic ion secretion was investigated in the rat in-vivo. 5-HT and the 5-HT1-, 5-HT2- and 5-HT4-receptor agonist 5-methoxytryptamine (5-MeOT), induced a rise in transintestinal PD in all regions of the gut. However, the 5-HT4-receptor agonists renzapride and cisapride had no effect. Furthermore, the 5-HT4-receptor antagonists SDZ 205-557 (2-diethylaminoethyl-[2-methoxy-4-amino-5-chloro] benzoate), tropisetron and SB 204070 ([1-butyl-4-piperidinylmethyl]-8-amino-7-chloro-1,4- benzodioxan-5-carboxylate hydrochloride) did not affect the secretory response to either 5-HT or 5-MeOT in the jejunum, but did cause a small inhibition in the ileum and colon. It is concluded that 5-HT4 receptors do not make a contribution to the electrically monitored 5-HT intestinal secretory response in the rat jejunum in-vivo, but may play a small role in the ileum and colon.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP137196679	SDZ-205,557 hydrochloride		137196-67-9	Price

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