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Docosahexaenoyl Ethanolamide Mitigates IgE-mediated Allergic Reactions by Inhibiting Mast Cell Degranulation and Regulating Allergy-Related Immune Cells

Docosahexaenoyl Ethanolamide Mitigates IgE-mediated Allergic Reactions by Inhibiting Mast Cell Degranulation and Regulating Allergy-Related Immune Cells

Kosuke Nishi, Yoshiki Kanayama, In-Hae Kim, Akihiro Nakata, Hisashi Nishiwaki, Takuya Sugahara

Sci Rep. 2019 Nov 7;9(1):16213.

PMID: 31700043

Abstract:

Docosahexaenoic acid (DHA) is a long-chain polyunsaturated fatty acid mainly found in fish oil. Although several studies have suggested that it can alleviate allergy symptoms, its mechanism of action remains to be elucidated. In the present study, we found that docosahexaenoyl ethanolamide (DHEA), a metabolite of DHA produced in the human body, exerts the anti-allergic activity in vitro and in vivo. DHEA suppressed degranulation of rat basophilic leukemia RBL-2H3 cells and bone marrow-derived mast cells in a dose-dependent manner without cytotoxicity. This occurred due to a decrease in Ca2+ influx, which is critical for mast cell degranulation. DHEA also suppressed IgE-mediated passive cutaneous anaphylaxis reaction in mice. In addition, DHEA was demonstrated to lessen an allergic symptom in a mouse model of pollinosis and to alter the production of IgE and cytokines secreted by splenocytes collected from the pollinosis mice. Taken together, this study indicates that DHEA is a promising anti-allergic agent as it inhibits mast cell degranulation and modulates other immune cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP162758943	Docosahexaenoyl ethanolamide		162758-94-3	Price

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