Home
Resources
Publications
Domino Effect of IL-15 and CD8 T Cell-Mediated Neuronal Apoptosis in Experimental Traumatic Brain Injury

Domino Effect of IL-15 and CD8 T Cell-Mediated Neuronal Apoptosis in Experimental Traumatic Brain Injury

Liang Wu, Ning-Ning Ji, Hang Wang, Jing-Yu Hua, Guo-Lin Sun, Pan-Pan Chen, Rong Hua, Yong-Mei Zhang

J Neurotrauma. 2018 Nov 15.

PMID: 30430911

Abstract:

The effects of local factors on the activation of immune cells infiltrating the CNS in rat model of traumatic brain injury (TBI) remains to be defined. The cytokine IL-15 is crucial in the development and activation of CD8 T lymphocytes, a prominent lymphocytic population identified in TBI lesions. We investigated whether IL-15 originates from astrocytes as well as evoke the CD8 T lymphocyte response in TBI. We observed that astrocytes were activated in TBI rat model, with IL-15 overexpressed on the astrocytic surface. Furthermore, the infiltrating CD8 T lymphocytes in the TBI lesions were adjacent to the IL-15-expressing astrocytes. Subsequently, CD8 T lymphocytes released Gra-b, which in turn activated Caspase-3 and cleaved PARP, and ultimately induced neuronal apoptosis. Conversely, inhibition of astrocytes by fluorocitrate (FC) pretreatment resulted in the improved neurological function and memory, as well as downregulation of IL-15 and CD8 T cells, and decreased neuronal apoptosis. In contrast, recombinant rat IL-15 (rIL-15) pretreatment upregulated the levels of CD8 T cells and Gra-b, and induced neuronal apoptosis. We concluded that IL-15 could induce neuronal apoptosis by enhancing CD8 T cell function in the rat model of TBI.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413354	IL-15 from rat			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: