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Dose-dependency of Multiple Free Radical-Scavenging Activity of Edaravone

Dose-dependency of Multiple Free Radical-Scavenging Activity of Edaravone

Osamu Tokumaru, Yachiko Shuto, Kazue Ogata, Masato Kamibayashi, Kira Bacal, Hidehiro Takei, Isao Yokoi, Takaaki Kitano

J Surg Res. 2018 Aug;228:147-153.

PMID: 29907205

Abstract:

Background:
Edaravone is a powerful free radical scavenger that is in clinical use. However, data concerning its dose-response relationship against multiple free radicals remain sparse. The purpose of the present study was to demonstrate the dose-dependency of direct scavenging activity of edaravone against multiple free radical species.
Materials and methods:
Free radical-scavenging activities of edaravone against six free radical species were evaluated by electron spin resonance spectroscopy using spin-trapping method.
Results:
Edaravone scavenged the following free radicals in dose-dependent manners with reaction rate constants (kedaravone) or 50% inhibitory concentration (IC50) as indicated: hydroxyl radical (kedaravone = 5.2 × 1010 M-1 s-1), superoxide anion (kedaravone/kG-CYPMPO = 0.63), tert-butyl peroxyl radical (kedaravone/kG-CYPMPO = 8.8), ascorbyl free radical (IC50 = 0.17 ± 0.06 mM), 2,2-diphenyl-1-picrylhydrazyl (DPPH, IC50 = 4.7 ± 0.3 μM), and nitric oxide (kedaravone = 7.0 × 103 M-1 s-1).
Conclusions:
The dose-dependent scavenging activities of edaravone against multiple free radical species were clearly illustrated. It is speculated that edaravone acts as antioxidant by dose-dependently scavenging multiple free radical species along the chain reactions of oxidative stress in surgery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP934182099	CYPMPO		934182-09-9	Price

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