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Double-blind Comparison of Carbenicillin Indanyl Sodium, Ampicillin, and Cephalexin in Treatment of Urinary Tract Infection

Double-blind Comparison of Carbenicillin Indanyl Sodium, Ampicillin, and Cephalexin in Treatment of Urinary Tract Infection

K M Ries, C G Cobbs, J Y Gillenwater, M E Levison, G L Mandell, M A Sande, D Kaye

Antimicrob Agents Chemother. 1973 Dec;4(6):593-6.

PMID: 4602827

Abstract:

Carbenicillin indanyl sodium, ampicillin, or cephalexin was administered orally to 61 patients with urinary tract infections. Assignment of drug was made by a computer-generated, randomized plan in a double-blind fashion. The rates of cure 4 weeks after therapy were 50, 42, and 50% for patients treated with carbenicillin, ampicillin, and cephalexin, respectively. Failure of therapy was correlated with chronicity of infection and sensitivity of the microorganism to the antibiotic used. Thirty-nine percent of the patients developed side effects, but there were no significant differences in side effects among the three antibiotics. This double-blind study demonstrates that carbenicillin indanyl sodium is as effective as ampicillin and cephalexin in treatment of urinary tract infections.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP26605696	Carbenicillin indanyl sodium		26605-69-6	Price

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