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Droplet-Based Microfluidic Templating of Polyglycerol-Based Microgels for the Encapsulation of Cells: A Comparative Study

Droplet-Based Microfluidic Templating of Polyglycerol-Based Microgels for the Encapsulation of Cells: A Comparative Study

Era Kapourani, Falko Neumann, Katharina Achazi, Jens Dernedde, Rainer Haag

Macromol Biosci. 2018 Oct;18(10):e1800116.

PMID: 29992778

Abstract:

Cell microencapsulation holds great promise as a therapeutic strategy for the controlled and sustained delivery of biologically relevant agents. The authors developed cell-laden microgel scaffolds with excellent long-term viabilities by combining bioorthogonal strain promoted azide-alkyne cycloaddition (SPAAC) and droplet-based microfluidic templating. Star-shaped polyglycerol hexaazide, α,ω-bis azido-linear polyglycerol or polyethylene glycol as well as dendritic polyglycerol-(polycyclooctyne) served as bioinert hydrogel precursors. The authors demonstrate for the first time the generation of entirely polyglycerol-based microcapsules with excellent stability and full retention of viability of the packed cells for longer than 3 weeks. As a result, our microgel particles could be used for long-term immunoisolation of cells enabling their study during encapsulation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP82055945-A	Polyoxyethylene bis(azide)		82055-94-5	Price

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