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Drug-excipient Compatibility Studies in Binary Mixtures of Avobenzone

Drug-excipient Compatibility Studies in Binary Mixtures of Avobenzone

Rita Ceresole, Yong K Han, Maria A Rosasco, Liliana R Orelli, Adriana Segall

J Cosmet Sci. Sep-Oct 2013;64(5):317-28.

PMID: 24139431

Abstract:

During preformulation studies of cosmetic/pharmaceutical products, thermal analysis techniques are very useful to detect physical or chemical incompatibilities between the active and the excipients of interest that might interfere with safety and/or efficacy of the final product. Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of avobenzone with some currently used cosmetic excipients. In the first phase of the study, DSC was used as a tool to detect any interaction. Based on the DSC results alone, cetearyl alcohol, isopropyl myristate, propylparaben, diethylhexyl syringylidene malonate, caprylic capric triglyceride, butylated hydroxytoluene (BHT), glycerin, cetearyl alcohol/ceteareth 20, cetearyl alcohol/sodium lauryl sulfate/sodium cetearyl sulfate, and paraffinum liquidum exhibit interaction with avobenzone. Stressed binary mixtures (stored at 50°C for 15 days) of avobenzone and excipients were evaluated by high-performance liquid chromatography. Binary mixtures were further investigated by infrared (IR) spectroscopy. Based on DSC, isothermal stress testing, and fourier transform infrared results; avobenzone is incompatible with caprylic capric triglyceride, propylparaben, and BHT.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP112301-A	Capric alcohol		112-30-1	Price

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