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Drug Release Kinetics From Carboxymethylcellulose-Bacterial Cellulose Composite Films

Drug Release Kinetics From Carboxymethylcellulose-Bacterial Cellulose Composite Films

Gheorghe Juncu, Anicuta Stoica-Guzun, Marta Stroescu, Gabriela Isopencu, Sorin Ion Jinga

Int J Pharm. 2016 Aug 30;510(2):485-92.

PMID: 26688041

Abstract:

Composite films of sodium carboxymethyl cellulose and bacterial cellulose (NaCMC-BC) cross-linked with citric acid (CA) were prepared by solution casting method. Ibuprofen sodium salt (IbuNa) has been used to study the mechanism of drug release from composite films. Surface morphology was investigated by scanning electron microscopy (SEM) and proved that the BC content influences the aspect of the films. Fourier transformed infrared spectroscopy (FTIR) revealed specific peaks in IR spectra of composite films which sustain that NaCMC was cross-linked with CA. Starting from swelling observations, the release kinetic of IbuNa was described using a model which neglects the volume expansion due to polymer swelling and which considers non-linear diffusion coefficients for drug and solvent. The IbuNa release is also influenced by BC content, the drug release rate was decreasing with the increase of BC content.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP31121934	Ibuprofen sodium salt		31121-93-4	Price

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