Home
Resources
Publications
Dual Controlled Delivery of Squalenoyl-Gemcitabine and Paclitaxel Using Thermo-Responsive Polymeric Micelles for Pancreatic Cancer

Dual Controlled Delivery of Squalenoyl-Gemcitabine and Paclitaxel Using Thermo-Responsive Polymeric Micelles for Pancreatic Cancer

Mandana Emamzadeh, Didier Desmaële, Patrick Couvreur, George Pasparakis

J Mater Chem B. 2018 Apr 21;6(15):2230-2239.

PMID: 32254563

Abstract:

In this study we report the synthesis of a themroresponsive block copolymer by reversible addition fragmentation transfer polymerization comprising poly(2-ethylhexyl methacrylate)-b-poly[di(ethylene glycol)methyl ether methacrylate-co-oligo(ethylene glycol)methyl ether methacrylate] as hydrophobic and thermoresponsive blocks respectively. The polymer self-assembles into sub-50 micelles and can carry simultaneously two drug molecules, namely squalene-gemcitabine and paclitaxel. Both drugs can be released from the micellar compartment in a thermally controlled manner owing to the controllable disruption of the micellar corona above the lower critical solution temperature of the polymer. We demonstrate that the formulation augments synergistically the cytotoxicity of the two drugs in vitro against a model pancreatic cancer cell line. More importantly, it is shown that the polymer exerts a direct interaction with the cell membrane which further augments the cytotoxicity of the drug cargo in a thermally controlled manner.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25719511	Poly(2-ethylhexyl methacrylate) solution		25719-51-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: