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Dynamic Changes in Plasma Tissue Plasminogen Activator, Plasminogen Activator inhibitor-1 and Beta-Thromboglobulin Content in Ischemic Stroke

Dynamic Changes in Plasma Tissue Plasminogen Activator, Plasminogen Activator inhibitor-1 and Beta-Thromboglobulin Content in Ischemic Stroke

Ping Zhuang, Da Wo, Zeng-Guang Xu, Wei Wei, Hui-ming Mao

J Clin Neurosci. 2015 Jul;22(7):1123-7.

PMID: 26002716

Abstract:

The aim of this paper is to investigate the corresponding variations of plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) activities, and beta-thromboglobulin (β-TG) content in patients during different stages of ischemic stroke. Ischemic stroke is a common disease among aging people and its occurrence is associated with abnormalities in the fibrinolytic system and platelet function. However, few reports focus on the dynamic changes in the plasma fibrinolytic system and β-TG content in patients with ischemic stroke. Patients were divided into three groups: acute, convalescent and chronic. Plasma t-PA and PAI-1 activities were determined by chromogenic substrate analysis and plasma β-TG content was detected by radioimmunoassay. Patients in the acute stage of ischemic stroke had significantly increased levels of t-PA activity and β-TG content, but PAI-1 activity was significantly decreased. Negative correlations were found between plasma t-PA and PAI-1 activities and between plasma t-PA activity and β-TG content in patients with acute ischemic stroke. There were significant differences in plasma t-PA and PAI-1 activities in the aged control group, as well as in the acute, convalescent and chronic groups. It can be speculated that the increased activity of t-PA in patients during the acute stage was the result of compensatory function, and that the increase in plasma β-TG level not only implies the presence of ischemic stroke but is likely a cause of ischemic stroke. During the later stages of ischemic stroke, greater attention is required in monitoring levels of PAI-1.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4246520	Tissue plasminogen activator chromogenic substrate			Price

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