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Early Adolescent Stress-Induced Changes in Prefrontal Cortex miRNA-135a and Hippocampal miRNA-16 in Male Rats

Early Adolescent Stress-Induced Changes in Prefrontal Cortex miRNA-135a and Hippocampal miRNA-16 in Male Rats

Yuan Liu, Dexiang Liu, Jingjing Xu, Hong Jiang, Fang Pan

Dev Psychobiol. 2017 Dec;59(8):958-969.

PMID: 28944448

Abstract:

Early-life stress increases susceptibility to post-traumatic stress disorders (PTSD), in which the dysfunction of 5-hydroxytryptamine plays an important role. miRNA-135a in the prefrontal cortex (PFC) and miRNA-16 in the hippocampus (HIP) are closely related to the 5-HT neurotransmitter system. Here, we investigated behavior, miRNA-135a in the PFC, miRNA-16 in the HIP, and 5-HT1AR expression in both brain regions in adolescent and adult rats that were exposed to inescapable stress during their adolescence. Paroxetine hydrochloride and corticotropin-releasing factor antagonist (CP-154,526) were used as intervening measures. Our study demonstrated that early adolescent stress induced anxiety-like behaviors and spatial memory damage, a reduction in miRNA-135a expression was associated with increased 5-HT1AR expression in PFC, and increased miRNA-16 expression in the HIP of stressed rats. Drug treatments alleviated behaviors and reversed the miRNA-135a, miRNA-16, and 5-HT1AR expression in stressed rats.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP257639988	CP-154526 hydrochloride		257639-98-8	Price

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