Home
Resources
Publications
Edetate Calcium Disodium Nanoparticle Dry Powder Inhalation: A Novel Approach Against Heavy Metal Decorporation

Edetate Calcium Disodium Nanoparticle Dry Powder Inhalation: A Novel Approach Against Heavy Metal Decorporation

Neeraj Kumar, Sandeep Soni, Abhinav Jaimini, Farhan Jalees Ahmad, Aseem Bhatnagar, Gaurav Mittal

Int J Pharm. 2011 Sep 15;416(1):376-83.

PMID: 21740960

Abstract:

Objective was to develop and characterize nano-edetate calcium disodium (Ca-Na(2)EDTA) dry powder inhaler (DPI), and assess its in vitro and in vivo deposition using pharmacoscintigraphy techniques. Factors influencing nanoparticle formation including concentration of drug, polymer solution and stirring rate were determined. Optimized formulation was characterized with the help of SEM, TEM and Malvern Zetasizer studies. Any change in physical characteristics after nanosizing was determined by FT-IR, XRD and DSC studies. Anderson cascade impaction showed that nano Ca-Na(2)EDTA exhibited significantly higher respirable fraction of 67.35±2.27% and 66.40±2.87% by scintigraphic and spectroscopic analysis respectively, as compared to 10.08±1.17% and 9.36±1.02% respectively for micronized form. Ventilation lung scintigraphy done in 12 volunteers showed significant increase in drug delivery till alveolar region with nano Ca-Na(2)EDTA. The developed formulation may have a role in neutralizing heavy metal toxicity through inhalation route, including radio-metal contamination.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23411349-A	Edetate Calcium Disodium		23411-34-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: