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Edetate Disodium-Based Treatment for Secondary Prevention in Post-Myocardial Infarction Patients

Edetate Disodium-Based Treatment for Secondary Prevention in Post-Myocardial Infarction Patients

Gervasio A Lamas, Omar M Issa

Curr Cardiol Rep. 2016 Feb;18(2):20.

PMID: 26797807

Abstract:

An abundance of data, known for decades, is available linking metals, such as lead and cadmium, with cardiovascular disease. However, the idea that these toxic metals could be a modifiable risk factor for atherosclerosis did not become apparent clinically until the completion of the Trial to Assess Chelation Therapy in 2012. This pivotal study was the first double-blind, randomized, controlled trial of its kind to demonstrate a clear improvement in cardiovascular outcomes with edetate disodium therapy in a secondary prevention, post-myocardial infarction population. This effect size was most striking in diabetic patients, where the efficacy of edetate disodium was comparable, if not superior, to that of current guideline-based therapies. Given the economic burden of diabetes and cardiovascular disease, the potential impact of this therapy could be enormous if the results of this study are replicated.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6381926-A	Edetate disodium		6381-92-6	Price

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