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Effect of 2,5-dimethylpyrazine on Uterine Contraction in Late Stage of Pregnant Female Rats

Effect of 2,5-dimethylpyrazine on Uterine Contraction in Late Stage of Pregnant Female Rats

Kenji Yamada, Miwa Sano, Hisato Fujihara, Akihiro Ohta

Biol Pharm Bull. 2003 Nov;26(11):1614-7.

PMID: 14600412

Abstract:

Effect of 2,5-dimethylpyrazine (2,5-DMP) on oxytocic agent-induced late pregnant uterine contraction in female rats was studied. Oxytocic agents induced-hypercontraction in the late phase of pregnant uterine movements were inhibited by administration of 2,5-DMP. The inhibition of uterine contraction was obtained more strengthening by presence of a low dose of ritodrine hydrochloride than 2,5-DMP alone. These results suggests that 2,5-DMP has an inhibitory action on uterine hypercontraction induced by oxytocic agent through the beta2-adrenoceptor in the pregnant uterus and supports the applicability of relaxing drugs for oxytocic agent-induced accidents.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP123320	2,5-Dimethylpyrazine		123-32-0	Price

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