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Effect of a Novel Fully Human Monovalent Antigen-Binding Fragment on the Survival of Cancer Cell Lines

Effect of a Novel Fully Human Monovalent Antigen-Binding Fragment on the Survival of Cancer Cell Lines

Yong Soon Kwon, You-Ri Lee, Yong-Sung Kim, Hyun-Wook Lee, Young-Ju Jang

Oncol Rep. 2007 Aug;18(2):513-7.

PMID: 17611678

Abstract:

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine having potent cytotoxic activity specifically to tumor cells. Agonistic antibodies against TRAIL receptors are currently being explored as anti-cancer therapeutics. Here, we report studies on JKTR-18, a monovalent human monoclonal antibody Fab selected against human recombinant TRAIL receptor 2 (DR5) by phage display technology. It induced cell death in Jurkat and HL60 leukemia cell lines without the need for secondary crosslinkers in vitro. It did not compete with soluble TRAIL (sTRAIL) for binding to DR5, and its combination with sTRAIL resulted in greater cell death than either agent alone. The cell death induced by JKTR-18 included a caspase-independent mechanism. This is the first report of a monovalent antibody fragment against TRAIL receptor that can induce tumor cell death in the absence of a crosslinker.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248886	sTRAIL Receptor-2 (DR5) human			Price

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