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Effect of Adenosine 3'-5'-cyclic Monophosphate on Cell Proliferation

Effect of Adenosine 3'-5'-cyclic Monophosphate on Cell Proliferation

J E Froehlich, M Rachmeler

J Cell Biol. 1972 Oct;55(1):19-31.

PMID: 4347252

Abstract:

Secondary cultures of human diploid fibroblasts, which demonstrate density-dependent inhibition of cell growth, were used to study the effect of adenosine 3'-5'-cyclic monophosphate (cAMP) on cell proliferation. DNA synthesis in nonconfluent cultures and in contact-inhibited cultures stimulated to grow by refeeding with fresh medium was found to be inhibited by exogenous cAMP. The properties of this inhibition of DNA synthesis, together with the alterations in cAMP metabolism observed in confluent cultures of cells stimulated with fresh medium to resume growth, strongly suggest that cAMP is involved in contact-inhibition of cell proliferation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP60924	Adenosine 3′,5′-cyclic monophosphate		60-92-4	Price

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