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Effect of Amrinone and Milrinone on Myocardial Ischemia Extent and Infarct Size in Isolated Rabbit Hearts

Effect of Amrinone and Milrinone on Myocardial Ischemia Extent and Infarct Size in Isolated Rabbit Hearts

A F Rump, B Blazincic, W Klaus

Arzneimittelforschung. 1993 Dec;43(12):1262-6.

PMID: 8141811

Abstract:

The effect of inotropics on myocardial ischemia is difficult to predict, since inotropics may influence the determinants of myocardial O2-demand and O2-supply differently. Several phosphodiesterase-inhibitors have been reported to possess antiischemic properties related in vivo to their hemodynamic and O2-sparing effects. The effects of amrinone (CAS 60719-84-8) (10(-6) mol/l or 5 x 10(-5) mol/l) or milrinone (CAS 78415-72-2) 10(-5) mol/l) on myocardial ischemia extent and infarct size were compared in isolated electrically paced rabbit hearts (Langendorff, constant pressure: 70 cm H2O, Tyrode solution, Ca2+ 1.8 mmol/l). Myocardial ischemia was induced by left coronary artery branch occlusion and quantitated from epicardial NADH-fluorescence photography. Infarct size was determined by Evan's blue dye and nitroblue-tetrazolium staining and planimetry. At low concentration (10(-6) mol/l), amrinone had no significant influence on left ventricular pressure or coronary flow (p < 0.05) and epicardial NADH-fluorescence area or infarct size were not significantly affected compared to controls (p > 0.05). Amrinone (5 x 10(-5) mol/l) or milrinone (10(-5) mol/l) significantly increased left ventricular pressure (+10%, p < 0.05) and coronary flow (+30, 40%, p < 0.05) to a similar extent. Concomitantly, both agents similarly reduced epicardial NADH-fluorescence area (-25%, p < 0.05) and infarct size relative to the area at risk or ventricle size compared to controls (p < 0.05).
Conclusion:
amrinone or milrinone possess comparable antiischemic effects in isolated rabbit hearts that seem to be related to coronary dilator activity of these agents.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP78415722-A	Milrinone - CAS 78415-72-2		78415-72-2	Price

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