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Effect of Betaine on S-adenosylmethionine Levels in the Cerebrospinal Fluid in a Patient With Methylenetetrahydrofolate Reductase Deficiency and Peripheral Neuropathy

Effect of Betaine on S-adenosylmethionine Levels in the Cerebrospinal Fluid in a Patient With Methylenetetrahydrofolate Reductase Deficiency and Peripheral Neuropathy

T Kishi, I Kawamura, Y Harada, T Eguchi, N Sakura, K Ueda, K Narisawa, D S Rosenblatt

J Inherit Metab Dis. 1994;17(5):560-5.

PMID: 7837762

Abstract:

A 16-year-old Japanese girl with 5,10-methylenetetrahydrofolate reductase deficiency showed peripheral neuropathy. There were no significant responses to vitamin B6, vitamin B12 or folate, given alone or in combination. With the addition of betaine monohydrate, she has been free from gait disturbance and muscle weakness. The concentration of S-adenosylmethionine in cerebrospinal fluid, which was undetectable before receiving betaine monohydrate, increased to about the normal level 24 months after treatment with betaine monohydrate.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP590476	Betaine monohydrate		590-47-6	Price

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