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Effect of Betulonic Acid and Its Derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic Acid on Liver Structure in Mice With RLS Lymphoma

Effect of Betulonic Acid and Its Derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic Acid on Liver Structure in Mice With RLS Lymphoma

N A Zhukova, D E Semenov, I V Sorokina, T G Tolstikova, S V Pozdnyakova, O R Grek

Bull Exp Biol Med. 2005 Sep;140(3):361-4.

PMID: 16307059

Abstract:

Morphological study of the effects of semisynthetic derivatives of betulin (betulonic acid and [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid) on the liver of CBA/Lac mice with transplanted RLS lymphoma was studied in the control and after cytostatic polychemotherapy. The number of small focal necroses decreased, while the counts of hepatocytes in a state of slight hyaline droplet degeneration increased. Morphometry of the main elements of liver parenchyma showed that alanine amide derivative of betulonic acid decreases the severity of necrotic and degenerative changes in the liver parenchyma, induced by cytostatic polychemotherapy. Betulonic acid exhibited no appreciable hepatoprotective effect under these conditions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP4481623	Betulonic acid		4481-62-3	Price

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