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Effect of Blue Light Irradiation on the Stability of Phospholipid Molecules in the Presence of epigallocatechin-3-gallate

Effect of Blue Light Irradiation on the Stability of Phospholipid Molecules in the Presence of epigallocatechin-3-gallate

Filipa Pires, Vananelia P N Geraldo, Andrea Antunes, Alexandre Marletta, Osvaldo N Oliveira Jr, Maria Raposo

Colloids Surf B Biointerfaces. 2019 May 1;177:50-57.

PMID: 30708310

Abstract:

In this paper, we report on the effects from epigallocatechin-3-gallate (EGCG), a phytochemical flavonoid present in green tea, on Langmuir monolayers of 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol) (sodium salt) (DPPG), including experiments with blue light irradiation. EGCG was found to interact with both the DPPG headgroups and hydrophobic tails, thus affecting the lipid packing according to surface pressure and surface potential isotherms and polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS) data. Blue light irradiation caused considerable changes in the surface pressure isotherms and PM-IRRAS spectra of DPPG monolayers, but the effects were considerably less when EGCG was present. For the surface pressure isotherms, for instance, no irradiation effect could be measured for mixed EGCG-DPPG monolayers. It is concluded that EGCG protected the DPPG molecules from degrading upon blue light irradiation, which means that EGCG may be a preventive and therapeutic agent to decrease photosensitivity of phospholipids to blue light oxidative damage, a pathogenic mechanism in skin disorders.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP1241726124	1,2-Dierucoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt	1241726-12-4	Price
AP200880428	1,2-Distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt	200880-42-8	Price
AP268550954	2-Oleoyl-1-palmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt	268550-95-4	Price

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