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Effect of Borneol as a Penetration Enhancer on Brain Targeting of Nanoliposomes: Facilitate Direct Delivery to Neurons

Effect of Borneol as a Penetration Enhancer on Brain Targeting of Nanoliposomes: Facilitate Direct Delivery to Neurons

Yue Wu, Shujun Wang, Lei Shang, Haifeng Zhang, Jianxiu Qin, Yating Ren, Tiantian Ye

Nanomedicine (Lond). 2018 Nov;13(21):2709-2727.

PMID: 30234427

Abstract:

Aim:
This study is aimed to evaluate borneol as a penetration enhancer to improve brain target of nanoliposome.
Materials & methods:
Effects of borneol on pharmacokinetics, targeting efficiency, brain subareas distribution and neuron-targeting level and pathway were studied by fluorescence spectrophotometry and immunofluorescence.
Results:
Borneol did not influence physicochemical property of doxorubicin hydrochloride nanoliposome (Dox-nanoLips). Co-administration of Dox-nanoLips with borneol elevated brain-target efficiency due to selective distribution increase in the cerebral cortex and hippocampus without difference in contralateral hemisphere. Borneol improved neuronal-targeting level of Dox-nanoLips in the cortex, CA3 and dentate gyrus regions via opening tight junctions of blood-brain barrier and then bypassing astrocyte.
Conclusion:
Borneol is potential to be a promising penetration enhancer for nanocarrier to target neurons.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP464437	(+)-Borneol		464-43-7	Price

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