Home
Resources
Publications
Effect of Bronkosol and Its Components on Cardiopulmonary Parameters in Asthmatic Patients

Effect of Bronkosol and Its Components on Cardiopulmonary Parameters in Asthmatic Patients

S L Spector, L Hudson, T L Petty

J Allergy Clin Immunol. 1977 May;59(5):371-6.

PMID: 323326

Abstract:

Bronkosol and its components, isoetharine hydrochloride and phenylephrine hydrochloride, were compared in a double-blind randomized fashion for their effect on pulmonary and cardiovascular parameters in patients with reversible bronchospasm. Bronkosol and isoetharine produced significant bronchodilatation as measured by forced expiratory volume in one second (FEV), forced vital capacity (FVC), and mean forced expiratory flow during the middle half of the FVC (isovolume FEF 25% to 75%), and phenylephrine did not. There was no difference between Bronkosol and isoetharine in the degree or duration of bronchodilatation. Significantly more patients had to "discontinue" after 15 min on the day of testing with phenylephrine than with Bronkosol or isoetharine. Heart rate was not increased after Bronkosol or isoetharine, confirming its selective beta-2 action. The addition of phenylephrine to isoetharine had no beneficial effect on oxygen saturation. There was no significant difference between these drugs in systolic and diastolic blood pressure, pulse, or respiration. The results of this study cast doubt on the useful contribution of phenylephrine in Bronkosol.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2576923	Isoetharine hydrochloride		2576-92-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: