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Effect of Carboprost Tromethamine in Prevention of Postpartum Hemorrhage in Cesarean Section

Effect of Carboprost Tromethamine in Prevention of Postpartum Hemorrhage in Cesarean Section

Zhang Ling, Liu Yao, Zhang Cui, Che Lifan

Pak J Pharm Sci. 2018 Sep;31(5(Special)):2257-2262.

PMID: 30463821

Abstract:

Carboprost tromethamine is a synthetic prostaglandin derivative, which can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery. In this study, we explored the effect of carboprost tromethamine on the prevention of postpartum hemorrhage after cesarean section and the effect on coagulation function and hemodynamics. At the same time, the effects of oxytocin and carboprost tromethamine were studied in different groups. The results showed that the amount of 2h bleeding (256.7±65.21) mL and the amount of 24h hemorrhage (308.3±78.3) after the operation were significantly decreased, and the difference was statistically significant (P<0.05). After the operation, the levels of APTT, TT and Fib in the two groups were significantly lower than those before the operation. The levels of SBP (119.4±8.24) mmHg and DBP (79.6±6.21) mmHg in the experimental group were significantly higher than those of the control group. In summary, carboprost tromethamine has a significant effect on the prevention of postpartum hemorrhage in cesarean section, and has a significant effect on improving the state of hypercoagulable blood and maintaining the stable hemodynamic state, which has clinical a value.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP77861-B	Tromethamine		77-86-1	Price

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