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Effect of Coffee Extracts on Plasma Fibrinolysis and Platelet Aggregation

Effect of Coffee Extracts on Plasma Fibrinolysis and Platelet Aggregation

Sawa Naito, Chieko Yatagai, Masugi Maruyama, Hiroyuki Sumi

Nihon Arukoru Yakubutsu Igakkai Zasshi. 2011 Apr;46(2):260-9.

PMID: 21702337

Abstract:

We have previously reported on study results showing that certain types of coffee have the activity to enhance fibrinolysis. This report covers the activity of 10 types of hot water extracts of coffee on human tissue-type plasminogen activator producing cells. Particularly strong activity (29-35 times the control amount) was observed for Blue Mountain, Yunnan and Kilimanjaro beans. It was found that the hot water extracts have anti-thrombin activity, and that coffee components have anti-platelet aggregation activity, although weak. It was revealed that there is no activity affecting tissue-type plasminogen activator producing cells in the coffee components chlorogenic acid, caffeine, quinic acid, trigonelline hydrochloride, 5-(hydroxymethyl)-2-furfuryl and caffeic acid. It was also revealed that there is activity in fractions with a molecular weight of 10,000 or less. This could also be inferred from the fact that oral administration of such fractions of coffee to human subjects resulted in a shortening of their plasma ELT (p<0.05).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6138416	Trigonelline hydrochloride		6138-41-6	Price

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