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Effect of Combined Oxidative and Nitrosative Stress on Neisseria Meningitidis

Effect of Combined Oxidative and Nitrosative Stress on Neisseria Meningitidis

K Dyet, J Moir

Biochem Soc Trans. 2006 Feb;34(Pt 1):197-9.

PMID: 16417521

Abstract:

Reactive oxygen and nitrogen species are produced by the human immune system in response to infection. Methods to detoxify these reactive species are vital to the survival of human pathogens, such as Neisseria meningitidis, which is the major aetiological agent of bacterial meningitis. Following activation, macrophages produce superoxide (O(2)(-)), hydrogen peroxide (H(2)O(2)) and nitric oxide (NO). The toxicity of O(2)(-), generated using X/Xo (xanthine/xanthine oxidase), and H(2)O(2) was investigated in the presence and absence of the NO donor DEA-NONOate [2-(N,N-diethylamino)-diazenolate-2-oxide diethylammonium salt]. Most of the toxicity from X/Xo was due to H(2)O(2). In N. meningitidis, NO decreased the toxicity of the H(2)O(2). In contrast, in the enteric bacterium Escherichia coli, NO increased the toxicity of the H(2)O(2).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP372965009	Diethylamine NONOate diethylammonium salt		372965-00-9	Price

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