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Effect of β-cyfluthrin (Synthetic Pyrethroid) on Learning, Muscular Coordination and Oxidative Stress in Swiss Albino Mice

Effect of β-cyfluthrin (Synthetic Pyrethroid) on Learning, Muscular Coordination and Oxidative Stress in Swiss Albino Mice

Neelu Kanwar Rajawat, Inderpal Soni, Farah Syed, Rajbala Verma, P J John, Reena Mathur

Toxicol Ind Health. 2019 May;35(5):358-367.

PMID: 31096887

Abstract:

The present study was planned to evaluate neurotoxic effects of β-cyfluthrin in female Swiss albino mice. Two doses of β-cyfluthrin, specifically, one-tenth of median lethal dose (LD50) and one-twentieth of LD50, were selected for the study. Open-field behaviour, exploratory behaviour and emotional status were affected, and animals showed anxiety-like behaviour after β-cyfluthrin administration. Spatial learning was decreased using the Hebb-Wiliams maze. Acetylcholinesterase enzyme activity significantly decreased in the treated animals. The administration of β-cyfluthrin caused increased lipid peroxidation (malondialdehyde) and decreased superoxide dismutase, catalase and glutathione peroxidase activity in brain tissue. In conclusion, β-cyfluthrin caused neurotoxicity as well as oxidative damage in the brain of Swiss albino mice at the tested dose levels.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1820573270	β-Cyfluthrin		1820573-27-0	Price

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