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[Effect of D-cellobiose on Oral Bioavailability of Gentiopicroside]

[Effect of D-cellobiose on Oral Bioavailability of Gentiopicroside]

Yun-Hao Dai, Man Wang, Ya-Nan Zhu, Lu-Lu Wang, Jian-Ming Ju, Zhen-Hai Zhang

Zhongguo Zhong Yao Za Zhi. 2016 May;41(10):1855-1859.

PMID: 28895332

Abstract:

In this study, the effect of D-cellobiose on oral bioavailability of gentiopicroside (GPS) was investigate. The influence of D-cellobiose on GPS was achieved by calculating the residual GPS after being degraded with β-glucosidase or intestinal flora, and the data demonstrated D-cellobiose could inhibit the degradation of GPS in intestines; in bioavailability experiment, D-cellobiose could significantly improve the oral bioavailability (P<0.05) of GPS at the mass ratio of 1∶5, 1∶10 (GPS-D-cellobiose). D-cellobiose applied in this study may improve the oral bioavailability of GPS through delaying the degradation in intestines.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP528507	D-(+)-Cellobiose		528-50-7	Price

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