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Effect of Dextran 70 on the Thermodynamic and Structural Properties of Proteins

Effect of Dextran 70 on the Thermodynamic and Structural Properties of Proteins

Gurumayum Suraj Sharma, Shruti Mittal, Laishram Rajendrakumar Singh

Int J Biol Macromol. 2015 Aug;79:86-94.

PMID: 25936502

Abstract:

Biological macromolecules are known to evolve and function under crowded intracellular environments that comprises of a wealth of soluble and insoluble macromolecules like proteins, nucleic acids, ribosomes and carbohydrates etc. Crowded environment is known to result in altered biological properties including thermodynamic, structural and functional aspect of macromolecules as compared to the macromolecules present in our commonly used experimental dilute buffers. In this study, we have investigated the effect of Dextran 70 on the thermodynamic and structural properties of three different proteins (Ribonuclease-A, lysozyme and holo α-lactalbumin) at different pH values. We discovered that Dextran 70 has a protein-independent effect in terms of protein stability and structure.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9004540-L	Dextran 70		9004-54-0	Price

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