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Effect of Gastric Secretion on Penetration of N-3H-methyl-N-nitro-N-nitrosoguanidine Into Gastric Mucosa of Rats

Effect of Gastric Secretion on Penetration of N-3H-methyl-N-nitro-N-nitrosoguanidine Into Gastric Mucosa of Rats

K K Ovrebø, H Sørbye, S Kvinnsland, K Grong, K Svanes

Dig Dis Sci. 1998 Sep;43(9):2012-20.

PMID: 9753267

Abstract:

Clinical conditions with low gastric acid secretion have been associated with increased risk of gastric cancer. There has also been concern about gastric acid inhibition and N-nitroso compound formation in the stomach. This study investigates the effect of gastric acid secretion on the penetration of N-3H-methyl-N-nitro-N-nitrosoguanidine, an N-nitroso compound and gastric carcinogen, into the gastric mucosa of rats. Gastric acid secretion was stimulated by pentagastrin (40 microg/kg/hr) and inhibited by omeprazole (40 micromol/kg) before mucosal exposure to N-3H-methyl-N-nitro-N-nitrosoguanidine. Penetration of the carcinogen was evaluated by light microscopic identification of cells in the S-phase labeled with N-3H-methyl-N-nitro-N-nitrosoguanidine. This population of double-labeled cells is considered at risk from N-methyl-N-nitro-N-nitrosoguanidine-induced carcinogenesis. The percentage of double-labeled cells was significantly higher in antrum than in corpus mucosa (P < 0.0001). Stimulation or inhibition of gastric acid secretion did not affect the penetration of N-3H-methyl-N-nitro-N-nitrosoguanidine in antrum or corpus mucosa. We conclude that modulation of gastric acid secretion does not affect the penetration of the carcinogen into the gastric mucosa nor does it explain the different penetration of the carcinogen into corpus and antrum mucosa.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS3103117	N′-Methyl Omeprazole			Price

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