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Effect of Ipratropium Bromide Treatment on Oxygen Saturation and Sleep Quality in COPD

Effect of Ipratropium Bromide Treatment on Oxygen Saturation and Sleep Quality in COPD

R J Martin, B L Bartelson, P Smith, D W Hudgel, D Lewis, G Pohl, P Koker, J F Souhrada

Chest. 1999 May;115(5):1338-45.

PMID: 10334150

Abstract:

Study objectives:
Patients with COPD are at risk of experiencing a deterioration in arterial oxygen saturation (SaO2) during sleep, which is generally most pronounced during rapid eye movement (REM) sleep. Increased cholinergic tone has been suggested as a contributing factor to this decrease in SaO2. Therefore, we investigated whether 4-week treatment with ipratropium bromide inhalation solution 0.02% (qid) could improve sleep characteristics in COPD.
Design:
Randomized, placebo-controlled, double-blind, two-arm parallel study of 4 weeks of treatment with ipratropium bromide solution or placebo.
Setting:
Multicenter investigation.
Patients:
Thirty-six patients with moderate-to-severe COPD (FEV1 < 65% of predicted).
Measurements and results:
Evaluation included polysomnographic, pulmonary function, and subjective quality of sleep (visual analog scale [VAS]) assessments. It was found that 4 week of treatment with ipratropium bromide solution in patients with COPD led to the following: (1) a significant (p = 0.05) improvement in mean nocturnal SaO2 with the more severe the nocturnal desaturation, the greater the improvement in SaO2; (2) significant (p = 0.03) improvement in perceived sleep quality (VAS: 5.5 +/- 0.5 after placebo; 7.2 +/- 0.5 after ipratropium); (3) a significant (p = 0.05) increase in REM sleep time (48.6 +/- 6.3 min after placebo; 66.5 +/- 6.4 min after ipratropium) with no effect on other sleep stages or total sleep time; and (4) a significant (p = 0.01) increase in pre-sleep FVC and flow rate at 50% of the vital capacity.
Conclusions:
These findings demonstrate that ipratropium bromide therapy can improve sleep SaO2 as well as sleep quality in patients with moderate-to-severe COPD.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7931692	2,4,6-Triisopropylphenylmagnesium bromide solution			Price

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