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Effect of JTC-801 (Nociceptin Antagonist) on Neuropathic Pain in a Rat Model

Effect of JTC-801 (Nociceptin Antagonist) on Neuropathic Pain in a Rat Model

Hidemichi Suyama, Masashi Kawamoto, Syafruddin Gaus, Osafumi Yuge

Neurosci Lett. 2003 Nov 20;351(3):133-6.

PMID: 14623124

Abstract:

JTC-801, a nociceptin antagonist, may alleviate neuropathic pain because nociceptin has been shown to produce pain modulation. We report that JTC-801 alleviates heat-evoked hyperalgesia and investigated the possible protective effect on osteoporosis induced by chronic constriction injury (CCI) in rats. JTC-801 was given orally to rats with CCI at 0% (vehicle), 0.03% (low dose), or 0.06% (high dose) in food. Paw withdrawal latency (PWL) to heat, bone mineral content (BMC) and bone mineral density (BMD) of the whole tibial bone were measured. JTC-801 dose-dependently normalized PWL. Although JTC-801 did not inhibit a CCI-induced decrease in BMC and BMD, it inhibited an increase in the number of osteoclasts in the JTC-801 groups. JTC-801, given orally in food, alleviated heat-evoked hyperalgesia in CCI rats, suggesting that it is useful for the treatment of neuropathic pain.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP244218517	JTC-801		244218-51-7	Price

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