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Effect of Long- And Short-Chain Perfluorinated Compounds on Cultured Thyroid Cells Viability and Response to TSH

Effect of Long- And Short-Chain Perfluorinated Compounds on Cultured Thyroid Cells Viability and Response to TSH

L Croce, F Coperchini, M Tonacchera, M Imbriani, M Rotondi, L Chiovato

J Endocrinol Invest. 2019 Nov;42(11):1329-1335.

PMID: 31102255

Abstract:

Purpose:
Perfluorinated chemicals are widespread pollutants persistent in the environment with links to some major health issues. The two main compounds, perfluoro-octanoic acid (PFOA) and perfluoro-alkyl sulphonate (PFOS), were recently classified as carcinogenetic and thus their use has been restricted. Short-chain PFCs were recently developed as an alternative, but no data regarding the possible endocrine toxicities of these compounds are available. Aim of this study was to investigate whether short-chain PFCs could jeopardize thyroid cell viability and/or interfere with the functional effect TSH.
Methods:
Fisher rat thyroid line-5 (FRTL-5) was treated with increasing concentrations of PFOA, PFOS, perfluorobutanesulfonic acid (PFBS), perfluorobutanoic acid (PFBA), pentafluoropropionic anhydride (PFPA), perfluoropentanoic acid (PFPeA) to evaluate modifications in cell viability and TSH-stimulated cAMP production.
Results:
Neither long nor short-chain PFCs affected cell viability (apart from PFOS 100 µM), or interfered with cAMP production.
Conclusions:
The results of the present study demonstrate for the first time that short-chain PFCs have no acute cytotoxic effect on thyroid cells in vitro and that cAMP production is not modulated by any of the tested PFCs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP356423	Pentafluoropropionic anhydride		356-42-3	Price

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