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Effect of Neutralization of Poly(methacrylic Acid-Co-Ethyl Acrylate) on Drug Release From Enteric-Coated Pellets Upon Accelerated Storage

Effect of Neutralization of Poly(methacrylic Acid-Co-Ethyl Acrylate) on Drug Release From Enteric-Coated Pellets Upon Accelerated Storage

Yanming Zu, Yi Luo, Salah Uddin Ahmed

Drug Dev Ind Pharm. 2007 Apr;33(4):457-73.

PMID: 17523010

Abstract:

The effect of neutralization of poly(methacrylic acid-co-ethyl acrylate) or poly(MA-EA) 1:1 (Eudragit L 30 D-55) on drug release from enteric-coated pellets was studied upon accelerated storage. The dissolution rate of un-neutralized poly(MA-EA)-coated pellets decreased while the neutralized polymer-coated pellets maintained a constant drug release rate. Dynamic mechanical analysis showed that both un-neutralized and neutralized poly(MA-EA) films became rigid on aging. However, the un-neutralized films were affected more than those neutralized. Neutralization of poly(MA-EA) significantly changed the mechanical properties of coating films and improved the stability of poly(MA-EA) enteric-coated pellets upon accelerated storage at the studied conditions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9010860	Poly(ethylene-co-ethyl acrylate)		9010-86-0	Price

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