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Effect of Phospholipase A2 Inhibitor ONO-RS-082 on Substance P-induced Histamine Release From Rat Peritoneal Mast Cells

M Kurosawa, T Hisada, T Ishizuka

Int Arch Allergy Immunol. 1992;97(3):226-8.

PMID: 1375204

Abstract:

Rat peritoneal mast cells purified on a Percoll gradient were challenged with substance P (SP) and the effect of phospholipase A2 inhibitor ONO-RS-082 on SP-induced histamine release from the cells was investigated. 10(-5) mol/l SP caused a significant histamine release and the amount of histamine release reached maximum at 1 min after the challenge. ONO-RS-082 inhibited the SP-induced histamine release in a concentration-dependent manner at the concentration from 10(-6) to 10(-4) mol/l, suggesting possible involvement of phospholipase A2 in SP-induced histamine release from rat peritoneal mast cells.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP99754060 ONO-RS-082 ONO-RS-082 99754-06-0 Price
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