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Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain-Chitosan Nanoparticles

Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain-Chitosan Nanoparticles

Janaína Artem Ataide, Eloah Favero Gérios, Letícia Caramori Cefali, Ana Rita Fernandes, Maria do Céu Teixeira, Nuno R Ferreira, Elias Basile Tambourgi, Angela Faustino Jozala, Marco Vinicius Chaud, Laura Oliveira-Nascimento, etc.

Polymers (Basel). 2019 Oct 15;11(10):1681.

PMID: 31618858

Abstract:

Bromelain, a set of proteolytic enzymes potential pharmaceutical applications, was encapsulated in chitosan nanoparticles to enhance enzyme stability, and the effect of different chitosan sources was evaluated. Chitosan types (i.e., low molecular weight chitosan, chitosan oligosaccharide lactate, and chitosan from shrimp shells) produced nanoparticles with different physicochemical properties, however in all cases, particle size and zeta potential decreased, and polydispersity index increased after bromelain addition. Bromelain encapsulation was higher than 84% and 79% for protein content and enzymatic activity, respectively, with low molecular weight chitosan presenting the highest encapsulation efficiency. Nanoparticle suspension was also tested for accelerated stability and rheological behavior. For the chitosan-bromelain nanoparticles, an instability index below 0.3 was recorded and, in general, the loading of bromelain in chitosan nanoparticles decreased the cohesiveness of the final suspension.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP148411578	Chitosan oligosaccharide lactate		148411-57-8	Price

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