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Effect of Putative Carcinoid Mediators on Gastric and Small Bowel Transit in Rats and the Role of 5-HT Receptors

Effect of Putative Carcinoid Mediators on Gastric and Small Bowel Transit in Rats and the Role of 5-HT Receptors

M A Valdovinos, G M Thomforde, M Camilleri

Aliment Pharmacol Ther. 1993 Feb;7(1):61-6.

PMID: 7679934

Abstract:

Whereas serotonin and substance P stimulate in-vivo and in-vitro myoelectric activity in the small intestine, their effects on transit are unclear. We used a validated in-vivo transit model in the chloral hydrate-anaesthetized rat to study the effects of serotonin, substance P and motilin, three putative mediators of carcinoid diarrhoea, on transit through the upper digestive tract. Intra-arterial serotonin accelerated gastric emptying of a radiolabelled liquid, while motilin accelerated overall upper gastrointestinal transit. Substance P slowed overall upper gastrointestinal transit without altering gastric emptying. The antagonists to serotonin receptor subtypes, R-zacopride (5-HT3) and ketanserin (5-HT2), also accelerated rat gastric emptying of liquids; in contrast, a 5-HT4 agonist, SC53116, resulted in a less pronounced effect on gastric emptying at the dose tested. We conclude that circulating substance P is unlikely to be an important accelerator of transit through the upper digestive tract; in contrast, hyperserotoninaemia significantly accelerates transit through the stomach, and 5-HT2 and 5-HT3 receptor subtypes may play a role in the motor effects of serotonin in the stomach.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
ALP101303984	Zacopride hydrochloride hydrate		101303-98-4 (anhydrous)	Price

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