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Effect of Salt Hydrate Pair on Lipase-Catalyzed Regioselective Monoacylation of Sucrose

Effect of Salt Hydrate Pair on Lipase-Catalyzed Regioselective Monoacylation of Sucrose

J E Kim, J J Han, J H Yoon, J S Rhee

Biotechnol Bioeng. 1998 Jan 5;57(1):121-5.

PMID: 10099186

Abstract:

Sucrose monoesters of a fatty acid were synthesized by using lipase in a solvent-free system. When lipase from Mucor miehei was used as a catalyst with capric acid as the donor and sugar as the acceptor, sucrose 6-monocaprate was predominantly produced in a yield of 25.3%. The yield of product was significantly increased by the direct addition of a suitable pair of solid salt hydrates to the reaction mixture to control the water activity (aw). Among the salt hydrate pairs investigated, the barium hydroxide, 8/1H2O pair resulted in the highest yield of the product. This salt addition method was also successfully employed for acylation of primary hydroxyl groups in various unprotected mono- and disaccharides such as glucose, galactose, fructose, trehalose, mannose, maltose, and lactose.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP40226300	Barium hydroxide hydrate		40226-30-0	Price

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