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Effect of Shenqi Compound Formula on PPARgamma in White Adipose Tissue of Rats With Macrovascular Lesion in Early Stage of Diabetes

Effect of Shenqi Compound Formula on PPARgamma in White Adipose Tissue of Rats With Macrovascular Lesion in Early Stage of Diabetes

Hongmin Zhang, Chunguang Xie, Shiwei Chen, Yiqiang Xie

J Tradit Chin Med. 2008 Jun;28(2):134-8.

PMID: 18652122

Abstract:

Objective:
To investigate the effect of Shenqi Compound Formula (SCF) on peroxisome proliferators-activated receptor gamma (PPARgamma) in white adipose tissue of rats with macrovascular lesion in early stage of diabetes.
Methods:
Corresponding treatment was given to rats in model group, Ramipril group, normal control group, low dosage SCF group and high dosage SCF group respectively for 32 days. The expressions of PPARgamma and adiponectin Messenger RNA (mRNA) were detected by real-time reverse transcriptase polymerase chain reaction.
Results:
The expressions of PPARgamma and adiponectin mRNA increased significantly in both low and high dosage SCF groups as compared with the model group, and a positive linear correlation was found between the expressions of PPARgamma and adiponectin mRNA.
Conclusions:
SCF can prevent macrovascular lesion in early stage of diabetes, which is possibly related with up-regulating expressions of PPARgamma and activating PPARgamma.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP108313117	Ramipril Related Compound A		108313-11-7	Price

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