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[Effect of Temperature on Drug Solubility in Complex Formation of Flubendazole and 2-hydroxypropyl-beta-cyclodextrin]

[Effect of Temperature on Drug Solubility in Complex Formation of Flubendazole and 2-hydroxypropyl-beta-cyclodextrin]

D Vetchý, M Rabisková, E Sucman

Ceska Slov Farm. 2000 Sep;49(5):239-41.

PMID: 11077730

Abstract:

Flubendazol is a veterinary antiparasitic agent which acts toxically on both adult and larval stages of round worms. It is nearly insoluble in water and it influences not only the selection of the dosage form, but also its biological availability. Its solubility can be increased by adding solutizers and tensides, or by complex-formation with cyclodextrins. In the published experimental paper the method of complex-formation of flubendazol with 2-hydroxypropyl-beta-cyclodextrin was employed and the effect of temperature on the resultant solubility of the active ingredient was examined. The final dosage form was pellets produced with the use of the method of extrusion and spheronisation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP31430156	Flubendazol		31430-15-6	Price

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