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Effect of the Intracerebroventricular Administration of GR 113808, a Selective 5-HT4 Antagonist, on Water Intake During Hyperosmolarity and Hypovolemia

Effect of the Intracerebroventricular Administration of GR 113808, a Selective 5-HT4 Antagonist, on Water Intake During Hyperosmolarity and Hypovolemia

L Castro, B Varjão, I Silva, B Duque, A Batista, R Santana, P Luz, M A Rocha Jr, J B Fregoneze, E De Castro-e-Silva

Braz J Med Biol Res. 2001 Jun;34(6):791-6.

PMID: 11378670

Abstract:

We demonstrate here that acute third ventricle injections of GR 113808, a highly selective 5-HT4 antagonist, decrease water intake induced by a previous salt load while potentiating drinking elicited by hypovolemia induced by previous subcutaneous administration of polyethylene glycol in male Wistar rats (200 +/- 20 g). At the dose of 160 nmol/rat, third ventricle injections of GR 113808 induced a significant reduction of water intake in salt-loaded animals after 120 min as compared to salt-loaded animals receiving third ventricle injections of saline (salt load + GR = 3.44 +/- 0.41 ml, N = 12; salt load + saline = 5.74 +/- 0.40 ml, N = 9). At the dose of 80 nmol/rat, GR 113808 significantly enhanced water intake in hypovolemic animals after 120 min as compared to hypovolemic animals receiving third ventricle injections of saline (hypovol + GR = 4.01 +/- 0.27 ml, N = 8; hypovol + saline = 2.41 +/- 0.23 ml, N = 12). We suggest that central 5-HT4 receptors may exert a positive drive on water intake due to hyperosmolarity and a negative input on drinking provoked by hypovolemia.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP144625514	GR 113808		144625-51-4	Price

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