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Effect of Trans, Trans-Farnesol on Pseudogymnoascus Destructans and Several Closely Related Species

Effect of Trans, Trans-Farnesol on Pseudogymnoascus Destructans and Several Closely Related Species

Daniel B Raudabaugh, Andrew N Miller

Mycopathologia. 2015 Dec;180(5-6):325-32.

PMID: 26162644

Abstract:

Bat white-nose syndrome, caused by the psychrophilic fungus Pseudogymnoascus destructans, has dramatically reduced the populations of many hibernating North American bat species. The search for effective biological control agents targeting P. destructans is of great importance. We report that the sesquiterpene trans, trans-farnesol, which is also a Candida albicans quorum sensing compound, prevented in vitro conidial germination for at least 14 days and inhibited growth of preexisting hyphae of five P. destructans isolates in filtered potato dextrose broth at 10 °C. Depending on the inoculation concentrations, both spore and hyphal inhibition occurred upon exposure to concentrations as low as 15-20 µM trans, trans-farnesol. In contrast, most North American Pseudogymnoascus isolates were more tolerant to the exposure of trans, trans-farnesol. Our results suggest that some Candida isolates may have the potential to inhibit the growth of P. destructans and that the sesquiterpene trans, trans-farnesol has the potential to be utilized as a biological control agent.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP106285	trans,trans-Farnesol		106-28-5	Price

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