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Effect of Tylosin Tartrate on Humoral Immune Responses in Chickens

Effect of Tylosin Tartrate on Humoral Immune Responses in Chickens

T Baba, N Yamashita, H Kodama, M Mukamoto, M Asada, K Nakamoto, Y Nose, E D McGruder

Zentralbl Veterinarmed B. 1998 Jun;45(5):279-86.

PMID: 9673579

Abstract:

While many antimicrobial agents have been reported to cause immunosuppression in animals, macrolide antibiotics enhance the immune function. Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry. The purpose of this investigation was to determine the effect of tylosin on the humoral immune functions in chickens. Three days after oral tylosin tartrate administration, 4- or 8-week-old chickens were immunized intravenously with carbolic acid-killed Brucella abortus bacterin or sheep red blood cells. Seven days (plasma antibodies titre) or 4 days (antibody forming cells) post-immunization, there was a significant increase in antibody production as well as in the numbers of antibody-producing cells in tylosin tartrate-administered chickens compared with the untreated controls. However, 3 days after tylosin tartrate administration, there was no difference in the distribution of T-lymphocyte subpopulations (CD4 or CD8 positive cells) or B lymphocytes (surface immunoglobulin positive cells) in either the peripheral blood or spleens or untreated control chickens.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS211207	Tylosin tartrate			Price

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