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Effect of Usnic Acid on Osteoclastogenic Activity

Effect of Usnic Acid on Osteoclastogenic Activity

Kwang-Jin Kim, Min-Hye Jeong, Yongjin Lee, Sue-Jeong Hwang, Han-Byeol Shin, Jae-Seoun Hur, Young-Jin Son

J Clin Med. 2018 Oct 12;7(10):345.

PMID: 30322046

Abstract:

Osteoclasts are the only cells that can resorb bone and they are produced from monocytes/macrophages in the presence of M-CSF and RANKL and are activated in vivo by an immune response. Usnic acid is a secondary metabolite of lichen and has a unique dibenzofuran skeleton. It has been used for years in cosmetics, fragrances, and traditional medicines. It has a wide range of bioactivities, including anti-inflammatory, anti-bacterial, anti-cancer, anti-viral, and so on. However, the anti-osteoclastogenic activity of usnic acid has not been reported yet. In this study, we investigated whether usnic acid could affect RANKL-mediated osteoclastogenesis. Usnic acid significantly inhibited RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1, a master regulator of osteoclastogenesis. In addition, it prevented lipopolysaccharides (LPS)-induced bone erosion in mice. Taken together, our results suggest that usnic acid might be a potential candidate for the treatment of osteoporosis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7562610	(+)-Usnic acid		7562-61-0	Price

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