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Effects of 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332), a New Enzyme Inducer, on the Microsomal Drug Metabolism. Part I

Effects of 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332), a New Enzyme Inducer, on the Microsomal Drug Metabolism. Part I

S Szeberényi, E Pálosi, L Szporny

Arzneimittelforschung. 1978;28(4):663-8.

PMID: 581944

Abstract:

Intensity and duration of action of several compounds which are metabolized in the liver, are reduced in rats following pretreatment with 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332, Zixoryn), e.g., hexobarbital, methohexitone, glutethimide, hydroxymephenesine, chlorzoxazone, zoxazolamine, ketamine, chlordiazepoxide, diphenylhydantoin, ethylmorphine and pentylenetetrazol, hydroquinone, acenocumarol, respectively. Hypnotic effect of barbital is not altered by RGH-3332. Hexobarbital, meprobamate, mephenesine, nikethamide, canrenone, metyrapone, antipyrine, bromsulphophthalein, inocyanin green, bilirubin disappearance are enhanced, excretion of ascorbic acid is increased after RGH-3332 treatment. The effect of RGH=3332 is inhibited by D,L-ethionine. Hepatic cytochrome P450 concentration is increased following treatment with RGH-3332. Results of in vivo studies proved that 3-trifluoromethyl-alpha-ethylbenzhydrol has enzyme inducing activity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5472139	Methylbenzhydrol		5472-13-9	Price

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