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Effects of 4-nonylphenol on oxidant/antioxidant Balance System Inducing Hepatic Steatosis in Male Rat

Effects of 4-nonylphenol on oxidant/antioxidant Balance System Inducing Hepatic Steatosis in Male Rat

Ansoumane Kourouma, Hady Keita, Peng Duan, Chao Quan, Koikoi Kebe Bilivogui, Suqin Qi, Ndjiembi Adjonga Christiane, Aidogie Osamuyimen, Kedi Yang

Toxicol Rep. 2015 Oct 19;2:1423-1433.

PMID: 28962484

Abstract:

An emerging literature suggests that early life exposure to 4-nonylphenol (4-NP), a widespread endocrine disrupting chemical, may increase the risk of metabolic syndrome. In this study, we investigated the hypothesis that intraperitoneal administration of 4-NP induces hepatic steatosis in rat. 24 male Sprague-Dawley rats were administered with 4-NP (0, 2, 10 and 50 mg/kg b.wt) in corn oil for 30 days. Liver histology, biochemical analysis and gene expression profiling were examined. After treatment, abnormal liver morphology and function were observed in the 4-NP-treated rat, and significant changes in gene expression an indicator of hepatic steatosis and apoptosis were observed compared with controls. Up-regulated genes involved in apoptosis, hepatotoxity and oxidative stress, increased ROS and decrease of antioxidant enzyme were observed in the 4-NP exposed rat. Extensive fatty accumulation in liver section and elevated serum GOT, GPT, LDH and γ-GT were also observed. Incidence and severity of liver steatosis was scored and taken into consideration (steatosis, ballooning and lobular inflammation). Hepatocytes apoptosis could promote NAFLD progression; Fas/FasL, TNF-α and Caspase-9 mRNA activation were important contributing factors to hepatic steatosis. These findings provide the first evidence that 4-NP affects the gene expression related to liver hepatotoxicity, which is correlated with hepatic steatosis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS2121227	Fluoride/Chloride in Oil			Price

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