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Effects of 8-aminoguanosine on the Toxicity of Guanosine and Deoxyguanosine for Malignant and Normal Lymphoid Cells

Effects of 8-aminoguanosine on the Toxicity of Guanosine and Deoxyguanosine for Malignant and Normal Lymphoid Cells

P M van der Kraan, P M van Zandvoort, R A De Abreu, J A Bakkeren

J Leukoc Biol. 1988 Jul;44(1):46-50.

PMID: 3164750

Abstract:

The toxicity of guanosine and deoxyguanosine in the presence or absence of the purine nucleoside phosphorylase inhibitor, 8-aminoguanosine, for malignant lymphoid cell lines and mitogen-stimulated peripheral blood lymphocytes has been studied. Deoxyguanosine inhibited the proliferation of lymphoid cells more strongly than guanosine. Addition of 100 microM 8-aminoguanosine neither enhanced nor diminished the toxicity of guanosine to the lymphoid cells. Only the toxicity of deoxyguanosine for the leukemic T cell line, MOLT 4, and the leukemic nonBnonT cell line, KM-3, was enhanced by the addition of 100 microM 8-aminoguanosine. These data suggest a possible role of purine nucleoside phosphorylase inhibitors in the treatment of lymphoproliferative disorders of the T-acute lymphoblastic leukemia (ALL) as well as the nonBnonT-ALL subclass.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3868324	8-Aminoguanosine		3868-32-4	Price

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