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Effects of a Synbiotic Yogurt Using Monk Fruit Extract as Sweetener on Glucose Regulation and Gut Microbiota in Rats With Type 2 Diabetes Mellitus

Effects of a Synbiotic Yogurt Using Monk Fruit Extract as Sweetener on Glucose Regulation and Gut Microbiota in Rats With Type 2 Diabetes Mellitus

Qingfeng Ban, Jianjun Cheng, Xiaomeng Sun, Yunqing Jiang, Shanbo Zhao, Xiao Song, Mingruo Guo

J Dairy Sci. 2020 Apr;103(4):2956-2968.

PMID: 32089310

Abstract:

We developed a synbiotic yogurt using monk fruit extract as a sweetener and investigated the effects of feeding the yogurt to rats with type 2 diabetes induced by streptozotocin and a high-fat diet. The rats fed the synbiotic yogurt showed greater blood glucose regulation and a significant decrease in insulin resistance and glycosylated hemoglobin compared with rats fed yogurt sweetened with sucrose, and they showed a remarkable improvement in short-chain fatty acid levels and gut microbiota status. Liver and kidney damage was also ameliorated in the rats fed the synbiotic yogurt. Immunohistochemistry analysis showed that the synbiotic yogurt inhibited β-cell loss compared with the control yogurt. Consuming the synbiotic yogurt helped to restore the islets of Langerhans. Our results indicated that monk fruit extract may be a good alternative to sucrose for synbiotic yogurt products in people with type 2 diabetes to delay the progression of diabetes and associated complications.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS31042376	Monk fruit extract			Price

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