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[Effects of Adenosine Triphosphate on the Postrotatory Nystagmus and Disorders of Vestibular Function (Author's Transl)]

[Effects of Adenosine Triphosphate on the Postrotatory Nystagmus and Disorders of Vestibular Function (Author's Transl)]

M Nakamura, T Yokoyama, Y Shirasawa, K Hirai, N Sano

Nihon Yakurigaku Zasshi. 1979 Jul;75(5):487-494.

PMID: 540880

Abstract:

Effects of adenosine triphosphate (ATP) on the postrotatory-induced nystagmus in rabbits and disorders of vestibular function induced by repeated administration of streptomycin in guinea pigs were studied. ATP-2Na exerted little influence on the postrotatory nystagmus in doses of 3 and 10 mg/kg, i.v., while slight suppressive effects were noted with a dose of 30 mg/kg. On the other hand, diphenidol hydrochloride remarkably suppressed the postrotatory nystagmus in a dose of 3 mg/kg i.v.. The disturbance in vestibular function following administration of streptomycin sulfate (400 mg/kg i.m., once daily x 9) was significantly alleviated when concomitant treatment with ATP-2Na (3 mg/kg i.p., 10 mg/kg i.p. and 100 mg/kg p.o., once daily x 14) or diphenidol hydrochloride (50 mg/kg p.o., once daily x 14) was given. ATP as well as diphenidol alleviated disorders in the vestibular function, while ATP had little influence on vestibular function in intact animals.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3254895	Diphenidol hydrochloride		3254-89-5	Price

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